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For patients without commercial insurance, there are other options for gaining access to Qbrelis:
Qbrelis is Affordable and Accessible
Backed by robust coverage and reimbursement support
- May be eligible for reimbursement by insurance plan.
- Reimbursed by Medicaid.
- Dedicated Prior Authorization Hotline (1-844-472-2032).
- Co-pay support and/or patient assistance available for qualifying patients.
Qbrelis Patients with Commercial Insurance May Pay No More Than $30 for a Qbrelis Prescription*
Backed by robust coverage and reimbursement support
Some of the participating pharmacies include:
- Real-time savings at many pharmacies with the Qbrelis co-pay programs.
- Automatic savings—Applies electronic coupon to co-pay.
- Completely paperless—No physician cards or coupons needed.
- These programs are for patients covered by commercial insurance.
- Costco Pharmacy
- CVS Pharmacy
- Duane Reade
- Genuardi’s Pharmacy
- Giant Pharmacy
- Harris Teeter
- Kroger Pharmacy
- Rite Aid Pharmacy
- Sam’s Pharmacy
- Target Pharmacy
- Walmart Pharmacy
For eVoucherRx™ questions
please call: 800‐388‐2316
Relay Pharmacy Help Desk/Customer Support.
Or you can Search Now
for a list of participating pharmacies.
For Voucher On Demand™ questions
, please call: 866-379-6389
eRxNetwork, LLC Help Desk/Customer Support.
- Qbrelis is covered by Medicaid.
- A patient assistance program is available for those who qualify.
Eligibility Restrictions, Terms, and Conditions
By participating in this savings program, participants understand and agree that the information provided, as well as non-personally identifiable information obtained from the pharmacy, will be shared with the manufacturer and with any companies working with the manufacturer. Participants also affirm that they will not submit, and have not had submitted on their behalf, a claim for reimbursement or coverage for items purchased with this card under Medicaid, Medicare, TRICARE, or any other federal or state government healthcare program, or where prohibited by state law.
eVoucherRx™ is a trademark of RelayHealth.
- Offer applies to out‐of‐pocket expenses (co‐pay) greater than $30. Out‐of‐pocket expenses greater than $30 will be covered up to $230 per prescription. If your total out‐of‐pocket cost exceeds $230, you will be responsible for a $30 co‐pay plus any additional amount over $230. If your co‐pay is already $30 or less, this offer does not apply.
- Offer applies only to Qbrelis patients and associated refills.
- This offer is not valid for prescriptions paid in part or in full by any federally or state‐funded program, including but not limited to Medicaid, Medicare, Department of Veterans Affairs, Department of Defense, or TRICARE, and where prohibited by law.
- For questions about eVoucherRx™, please call: 800‐388‐2316 Relay Pharmacy Help Desk/Customer Support.
- For questions about Voucher On Demand™, please call: 866‐379‐6389 eRxNetwork, LLC Help Desk/Customer Support.
- This savings program cannot be combined with any other coupon, certificate, voucher, or similar offer.
- Offer good only in the USA at participating retail pharmacies and cannot be redeemed at government‐subsidized clinics. Void where taxed, restricted, or prohibited by law.
- Offer not extended to clubs, groups, or organizations.
- Participation in this program must comply with all applicable laws and contractual or other obligations as a pharmacy provider.
- This is not an insurance program.
- Participating patients and pharmacists understand and agree to comply with the Terms and Conditions of this offer as set forth herein.
- Any step‐edits or prior authorizations required by the insurance plan still apply.
- Silvergate Pharmaceuticals, Inc. reserves the right to modify or cancel this program at any time.
- eVoucherRx™ and Voucher On Demand™ are not extended on prescriptions for patients:
- who are cash‐paying customers.
- using institution-based pharmacies to fill their prescriptions, or who are recipients of federal or state government health care.
- who are filling their prescriptions at nonparticipating pharmacies.
Voucher On Demand™ is a trademark of eRxNetwork, LLC.
IMPORTANT SAFETY INFORMATION✕
IMPORTANT SAFETY INFORMATION
WARNING: FETAL TOXICITY
See full Prescribing Information for complete boxed warning.
- When pregnancy is detected, discontinue QBRELIS as soon as possible.
- Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.
QBRELIS is an angiotensin-converting enzyme (ACE) inhibitor indicated for:
- treatment of hypertension in adult patients and pediatric patients 6 years of age and older to lower blood pressure (BP). Lowering BP decreases
the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions (MI).
- reduction of signs and symptoms of systolic heart failure.
- reduction of mortality in treatment of hemodynamically stable patients within 24 hours of acute MI. Patients should receive, as appropriate, the standard
recommended treatments such as thrombolytics, aspirin, and beta-blockers.
ADDITIONAL IMPORTANT SAFETY INFORMATION
See full Prescribing Information for further information, including other Adverse Reactions.
- Qbrelis is contraindicated in patients who are hypersensitive to lisinopril or any component of Qbrelis, or in patients with a history of hypersensitivity related
to previous ACE inhibitor treatment.
- Qbrelis is contraindicated in patients with hereditary or idiopathic angioedema and should not be co-administered with aliskiren in patients with diabetes.
- Qbrelis is contraindicated in combination with a neprilysin inhibitor (e.g., sacubitril). Do not administer Qbrelis within 36 hours of switching to or from sacubitrol/valsartan.
- Head and Neck Angioedema: Angioedema of the face, extremities, lips, tongue, glottis,
and/or larynx, including some fatal reactions, have occurred in patients treated with ACE
inhibitors, including Qbrelis, at any time during treatment. Patients with a history of
angioedema unrelated to ACE inhibitor therapy may be at increased risk of angioedema
while receiving an ACE inhibitor. ACE inhibitors have been associated with a higher rate
of angioedema in Black than non-Black patients.
- Intestinal angioedema has been reported with ACE inhibitors. Discontinue Qbrelis
and obtain appropriate therapy.
- Anaphylactoid Reactions: Sudden and potentially life-threatening anaphylactoid reactions
have occurred in some patients dialyzed with high-flux membranes treated concomitantly
with an ACE inhibitor. In such patients, dialysis must be stopped immediately, and
aggressive therapy for anaphylactoid reactions must be initiated. Symptoms have not
been relieved by antihistamines in these situations. In these patients, consideration should
be given to using a different type of dialysis membrane or a different class of
antihypertensive agent. Anaphylactoid reactions have also been reported in patients
undergoing low-density lipoprotein apheresis with dextran sulfate absorption and in
patients undergoing desensitizing treatment with hymenoptera venom.
- Impaired Renal Function: Monitor renal function in patients treated with Qbrelis.
Changes in renal function, including acute renal failure, can be caused by drugs that
inhibit the renin-angiotensin system (RAS). Patients whose renal function may depend
in part on the activity of the RAS (e.g., patients with renal artery stenosis, chronic
kidney disease, severe congestive heart failure, post-MI or volume depletion) may be
at particular risk of developing acute renal failure on Qbrelis. Consider withholding or
discontinuing therapy in patients who develop a clinically significant decrease in renal
function on Qbrelis
- Hypotension: Qbrelis can cause symptomatic hypotension, sometimes complicated by
oliguria, progressive azotemia, acute renal failure, or death. Qbrelis should be started
under close medical supervision and followed closely for the first 2 weeks of treatment
and whenever the dose of Qbrelis and/or a diuretic is increased. Avoid the use of
Qbrelis in hemodynamically unstable patients after acute MI.
- Surgery/Anesthesia: In patients undergoing major surgery or during anesthesia with
agents that produce hypotension, Qbrelis may block angiotensin II formation
secondary to compensatory renin release. If hypotension occurs and it is considered
to be due to this mechanism, it can be corrected by volume expansion.
- Hepatic Failure: ACE inhibitors have been associated with a syndrome that starts with
cholestatic jaundice and progresses to fulminant hepatic necrosis and sometimes
death. If jaundice or marked elevations of hepatic enzymes develop, discontinue the
ACE inhibitor and receive appropriate medical follow-up.
- Hyperkalemia: Serum potassium should be monitored in patients receiving Qbrelis.
Drugs that inhibit the renin-angiotensin system can cause hyperkalemia. Risk factors
for the development of hyperkalemia include renal insufficiency, diabetes mellitus, and
the concomitant use of potassium-sparing diuretics, potassium supplements, and/or
potassium-containing salt substitutes.
- Adverse Reactions (where rate on lisinopril exceeds the rate on placebo by at least
2%) occurring in greater than 1% of patients with:
- Hypertension: headache, dizziness, and cough.
- Systolic heart failure: hypotension and chest pain.
- Acute MI: hypotension and renal dysfunction.
Please see accompanying full Prescribing Information for additional Important Safety Information, including
- Initiation of Qbrelis in patients on diuretics may result in excessive reduction
of blood pressure. This can be minimized by either decreasing or discontinuing
the diuretic or increasing salt intake prior to initiating Qbrelis treatment.
- Qbrelis attenuates potassium loss caused by thiazide-type diuretics. If
concomitant use of such agents is indicated, monitor the patient’s serum
- Concomitant administration of Qbrelis and antidiabetic medicines may cause
an increased blood-glucose-lowering effect.
- In patients who are elderly, volume-depleted (as on diuretic therapy), or with
compromised renal function, use of non-steroidal anti-inflammatory agents
(NSAIDs), including selective cyclooxygenase-2 (COX-2) inhibitors, with ACE
inhibitors, including lisinopril, may result in deterioration of renal function,
including renal failure. Monitor renal function periodically in patients receiving
lisinopril and NSAID therapy.
- Dual Inhibition of the Renin-Angiotensin System (RAS): Dual blockade of the RAS
with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with
increased risks of hypotension, hyperkalemia, and changes in renal function
(including acute renal failure), compared to monotherapy. Closely monitor BP,
renal function and electrolytes in patients receiving Qbrelis and agents that
effect the RAS.
- Avoid use of aliskiren with Qbrelis in patients with renal impairment.
- Lithium toxicity has been reported in patients receiving lithium concomitantly with
drugs that cause elimination of sodium, including ACE inhibitors. It is usually
reversible upon discontinuation of lithium and the ACE inhibitor. Monitor serum
lithium levels during concurrent use.
- Nitritoid reactions have been reported rarely in patients with injectable gold
(sodium aurothiomalate) and concomitant lisinopril therapy.
- mTOR or neprilysin inhibitors: Patients receiving coadministratoin of an ACE inhibitor and a mTOR inhibitor (e.g., temsirolimus, sirolimus, everolimus) or a neprilysin inhibitor (e.g., sacubitril) may be at increased risk for angioedema.
- Concomitant use of Qbrelis with mammalian target of rapamycin (mTOR) inhibitor
therapy may increase the risk for angioedema.
- Because of the potential for severe adverse reactions in the breastfed infant, advise women not to breastfeed while taking Qbrelis.
- Qbrelis is not recommended in children under the age of 6 years or in
pediatric patients with glomerular filtration rate < 30 mL/min/1.73m2.
To report SUSPECTED ADVERSE REACTIONS, contact Silvergate Pharmaceuticals at 1-855-379-0383, or FDA at 1-800-FDA-1088 or www.fda.gov/MedWatch